Indicated in Cochlear Synaptic Tinnitus Cases
Indicated in cases of Tinnitus, Presbycusis, and Speech Discrimination
M.S. in ENT (Bom)
D.O.R.L. in ENT (Bom)
The results showed that after treatment, the Visual Analog Scale got decreased (3.66 ± 1.56) as compared to pre-treatment Visual Analog Scale (5.82 ± 1.38), which is highly significant (95% C.I.; P = 0.000). Overall the study results suggested 75- 80% success rate in reducing severity, intensity & duration of Tinnitus with enhanced hearing capacity.
It is the perception of sound within the human ear in the absence of corresponding external sound. Tinnitus can be perceived in one or both ears or in the head. It is usually described as a ringing noise, but in some patients it takes the form of a high pitched whining, electric, buzzing, hissing, screaming, humming, tinging or whistling sound, or as ticking, clicking, roaring, "crickets" or "tree frogs" or "locusts", tunes, songs, beeping, or even a pure steady tone like that heard during a hearing test. It has also been described as a "wooshing" sound, as of wind or waves. Tinnitus can be intermittent or it can be continuous, in which case it can be the cause of great distress. In some individuals, the intensity can be changed by shoulder, head, tongue, jaw, or eye movement
1. Objective (a clinician can perceive an actual sound (e.g., a bruit) emanating from the patient's ears.)
2. Subjective tinnitus (It is heard only by patient.) it is of three subtypes: Myoclonus, Cochlear, Retrocochlear
With certain investigations, now one may find out the exact cause of the damage to the hair cell and thus, the type of tinnitus. And henceforth, if the patient is treated accordingly, more than 90% of the patients can be treated.
Please note: serious toxic dose is 156 mg/kg body weight, as established in pre clinical trials. Hence, the recommended dose here is very safe. But, as overdose may increase the tinnitus, it is strongly recommended to follow the gradation system to avoid over dose. Infusion should be stopped before tinnitus becomes totally zero. This judgment depends on continuous observation of a clinician, how fast the patient and the symptom responds to initial infusion. So, infusion under close observation is must.
Tinnitus may increase. Although, in clinical trials, it was observed that such tinnitus will disappear by time without any treatment.
There is no harm in administering a repeat dose after 7 days. But, if patient does not respond in first dose, logic in repeating is perhaps excess of glutamate toxic granules is restricting the result. Although, in the cases where the patient feels even the slightest of change in the intensity or quality of tinnitus (following injection), a repeat dose is recommended.
Looking to half-life, C-max and T-max values of Caroverine, it is safe to repeat any time after 7 days. There is no statistical data available for the effects of repeat dose, or re-repeat dose.